7ROR

Plasmodium falciparum tyrosyl-tRNA synthetase in complex with tyrosine-AMP

7ROR の概要

• エントリーDOI: 10.2210/pdb7ror/pdb
• 分子名称: Tyrosine--tRNA ligase, 5'-O-[(S)-{[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]oxy}(hydroxy)phosphoryl]adenosine, MALONATE ION, ... (6 entities in total)
• 機能のキーワード: enzyme, tyrosyl-trna synthetase, malaria, inhibitor, ligase, tyrosine-amp
• 由来する生物種: Plasmodium falciparum (isolate 3D7)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 88679.90

構造登録者

Metcalfe, R.D.,Xie, S.C.,Morton, C.J.,Tilley, L.,Griffin, M.D.W. (登録日: 2021-08-02, 公開日: 2022-06-08, 最終更新日: 2023-10-18)

• 主引用文献: Xie, S.C.,Metcalfe, R.D.,Dunn, E.,Morton, C.J.,Huang, S.C.,Puhalovich, T.,Du, Y.,Wittlin, S.,Nie, S.,Luth, M.R.,Ma, L.,Kim, M.S.,Pasaje, C.F.A.,Kumpornsin, K.,Giannangelo, C.,Houghton, F.J.,Churchyard, A.,Famodimu, M.T.,Barry, D.C.,Gillett, D.L.,Dey, S.,Kosasih, C.C.,Newman, W.,Niles, J.C.,Lee, M.C.S.,Baum, J.,Ottilie, S.,Winzeler, E.A.,Creek, D.J.,Williamson, N.,Parker, M.W.,Brand, S.,Langston, S.P.,Dick, L.R.,Griffin, M.D.W.,Gould, A.E.,Tilley, L.; Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.; Science, 376:1074-1079, 2022; PubMed: 35653481; DOI: 10.1126/science.abn0611

実験手法

X-RAY DIFFRACTION (1.8 Å)