7RNM

Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with 2-(2-Chloro-5-phenylthieno[2,3-d]pyrimidin-4-yl)isoindolin-5-ol and GRIP Peptide

Summary for 7RNM

• Entry DOI: 10.2210/pdb7rnm/pdb
• Descriptor: Estrogen receptor, Nuclear receptor coactivator 2, 2-(2-chloro-5-phenylthieno[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-isoindol-5-ol, ... (4 entities in total)
• Functional Keywords: breast cancer, estrogen receptor, alpha helical bundle, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 60193.72

Authors

Joiner, C.,Sammeta, V.K.R.,Norris, J.D.,McDonnell, D.P.,Willson, T.M.,Fanning, S.W. (deposition date: 2021-07-29, release date: 2022-08-03, Last modification date: 2024-02-14)

• Primary citation: Reddy Sammeta, V.,Anderson, B.M.,Norris, J.D.,Torrice, C.D.,Joiner, C.,Liu, S.,Li, H.,Popov, K.I.,Fanning, S.W.,McDonnell, D.P.,Willson, T.M.; Structural Determinants of the Binding and Activation of Estrogen Receptor alpha by Phenolic Thieno[2,3-d]pyrimidines; Helv.Chim.Acta, 106:-, 2023; DOI: 10.1002/hlca.202300097

Experimental method

X-RAY DIFFRACTION (1.9 Å)