7RNM

Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with 2-(2-Chloro-5-phenylthieno[2,3-d]pyrimidin-4-yl)isoindolin-5-ol and GRIP Peptide

7RNM の概要

• エントリーDOI: 10.2210/pdb7rnm/pdb
• 分子名称: Estrogen receptor, Nuclear receptor coactivator 2, 2-(2-chloro-5-phenylthieno[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-isoindol-5-ol, ... (4 entities in total)
• 機能のキーワード: breast cancer, estrogen receptor, alpha helical bundle, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 60193.72

構造登録者

Joiner, C.,Sammeta, V.K.R.,Norris, J.D.,McDonnell, D.P.,Willson, T.M.,Fanning, S.W. (登録日: 2021-07-29, 公開日: 2022-08-03, 最終更新日: 2024-02-14)

• 主引用文献: Reddy Sammeta, V.,Anderson, B.M.,Norris, J.D.,Torrice, C.D.,Joiner, C.,Liu, S.,Li, H.,Popov, K.I.,Fanning, S.W.,McDonnell, D.P.,Willson, T.M.; Structural Determinants of the Binding and Activation of Estrogen Receptor alpha by Phenolic Thieno[2,3-d]pyrimidines; Helv.Chim.Acta, 106:-, 2023; DOI: 10.1002/hlca.202300097

実験手法

X-RAY DIFFRACTION (1.9 Å)