7RLE
Crystal structure of PPAR gamma in complex with CREB-binding protein and agonist GW1929
Summary for 7RLE
| Entry DOI | 10.2210/pdb7rle/pdb |
| Descriptor | Peroxisome proliferator-activated receptor gamma, CREB-binding protein, (2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid, ... (4 entities in total) |
| Functional Keywords | nuclear receptor, transcription factor, dna binding protein |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 68855.68 |
| Authors | Nemetchek, M.D.,Sprang, S.R.,Hughes, T.S. (deposition date: 2021-07-23, release date: 2022-08-03, Last modification date: 2023-10-25) |
| Primary citation | Nemetchek, M.D.,Chrisman, I.M.,Rayl, M.L.,Voss, A.H.,Hughes, T.S. A structural mechanism of nuclear receptor biased agonism. Proc.Natl.Acad.Sci.USA, 119:e2215333119-e2215333119, 2022 Cited by PubMed: 36469765DOI: 10.1073/pnas.2215333119 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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