7RIE

Plasmodium falciparum M17 in complex with inhibitor MIPS2571

7RIE の概要

• エントリーDOI: 10.2210/pdb7rie/pdb
• 分子名称: M17 leucyl aminopeptidase, CARBONATE ION, ZINC ION, ... (7 entities in total)
• 機能のキーワード: aminopeptidase, enzyme, malaria, peptide binding protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 712701.43

構造登録者

Webb, C.T.,McGowan, S. (登録日: 2021-07-19, 公開日: 2022-09-14, 最終更新日: 2023-10-25)

• 主引用文献: Edgar, R.C.S.,Siddiqui, G.,Hjerrild, K.,Malcolm, T.R.,Vinh, N.B.,Webb, C.T.,Holmes, C.,MacRaild, C.A.,Chernih, H.C.,Suen, W.W.,Counihan, N.A.,Creek, D.J.,Scammells, P.J.,McGowan, S.,de Koning-Ward, T.F.; Genetic and chemical validation of Plasmodium falciparum aminopeptidase Pf A-M17 as a drug target in the hemoglobin digestion pathway.; Elife, 11:-, 2022; PubMed: 36097817; DOI: 10.7554/eLife.80813

実験手法

X-RAY DIFFRACTION (2.49 Å)