7RFB
Crystal structure of broadly neutralizing antibody mAb1198 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain
Summary for 7RFB
Entry DOI | 10.2210/pdb7rfb/pdb |
Descriptor | mAb1198 Heavy Chain, mAb1198 Light Chain, envelope glycoprotein E2, ... (6 entities in total) |
Functional Keywords | hcv glycoprotein, broadly neutralizing antibodies, viral protein-immune system complex, viral protein/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 162210.42 |
Authors | Flyak, A.I.,Bjorkman, P.J. (deposition date: 2021-07-14, release date: 2022-01-12, Last modification date: 2023-10-18) |
Primary citation | Weber, T.,Potthoff, J.,Bizu, S.,Labuhn, M.,Dold, L.,Schoofs, T.,Horning, M.,Ercanoglu, M.S.,Kreer, C.,Gieselmann, L.,Vanshylla, K.,Langhans, B.,Janicki, H.,Stroh, L.J.,Knops, E.,Nierhoff, D.,Spengler, U.,Kaiser, R.,Bjorkman, P.J.,Krey, T.,Bankwitz, D.,Pfeifer, N.,Pietschmann, T.,Flyak, A.I.,Klein, F. Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization. Immunity, 55:341-354.e7, 2022 Cited by PubMed: 34990590DOI: 10.1016/j.immuni.2021.12.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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