7RFB

Crystal structure of broadly neutralizing antibody mAb1198 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain

7RFB の概要

• エントリーDOI: 10.2210/pdb7rfb/pdb
• 分子名称: mAb1198 Heavy Chain, mAb1198 Light Chain, envelope glycoprotein E2, ... (6 entities in total)
• 機能のキーワード: hcv glycoprotein, broadly neutralizing antibodies, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 162210.42

構造登録者

Flyak, A.I.,Bjorkman, P.J. (登録日: 2021-07-14, 公開日: 2022-01-12, 最終更新日: 2023-10-18)

• 主引用文献: Weber, T.,Potthoff, J.,Bizu, S.,Labuhn, M.,Dold, L.,Schoofs, T.,Horning, M.,Ercanoglu, M.S.,Kreer, C.,Gieselmann, L.,Vanshylla, K.,Langhans, B.,Janicki, H.,Stroh, L.J.,Knops, E.,Nierhoff, D.,Spengler, U.,Kaiser, R.,Bjorkman, P.J.,Krey, T.,Bankwitz, D.,Pfeifer, N.,Pietschmann, T.,Flyak, A.I.,Klein, F.; Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization.; Immunity, 55:341-354.e7, 2022; PubMed: 34990590; DOI: 10.1016/j.immuni.2021.12.003

実験手法

X-RAY DIFFRACTION (2.7 Å)