7REG

DfrA1 complexed with NADPH and 4'-chloro-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-[1,1'-biphenyl]-4-carboxamide (UCP1228)

7REG の概要

• エントリーDOI: 10.2210/pdb7reg/pdb
• 分子名称: Dihydrofolate reductase type 1, 4'-chloro-3'-[(2S)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl][1,1'-biphenyl]-4-carboxamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: inhibitor, complex, antifolate, dhfr, oxidoreductase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37550.74

構造登録者

Lombardo, M.N.,Wright, D.L. (登録日: 2021-07-12, 公開日: 2022-07-27, 最終更新日: 2023-10-18)

• 主引用文献: Krucinska, J.,Lombardo, M.N.,Erlandsen, H.,Estrada, A.,Si, D.,Viswanathan, K.,Wright, D.L.; Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens.; Commun Biol, 5:459-459, 2022; PubMed: 35562546; DOI: 10.1038/s42003-022-03384-y

実験手法

X-RAY DIFFRACTION (1.77 Å)