7REE
High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to YM2-059
Summary for 7REE
Entry DOI | 10.2210/pdb7ree/pdb |
Descriptor | Tyrosine-protein kinase JAK2, [3-(4-{2-[3,5-difluoro-4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1H-pyrazol-1-yl)-1-(ethanesulfonyl)azetidin-3-yl]acetonitrile (3 entities in total) |
Functional Keywords | kinase, janus kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35538.55 |
Authors | Karim, M.R.,Schonbrunn, E. (deposition date: 2021-07-12, release date: 2021-09-01, Last modification date: 2023-11-15) |
Primary citation | Karim, M.R.,Schonbrunn, E. High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to YM2-059. To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.38 Å) |
Structure validation
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