7RD4

Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody m43.149

Summary for 7RD4

• Entry DOI: 10.2210/pdb7rd4/pdb
• Descriptor: antibody m43.149 heavy chain, antibody m43.149 light chain, Circumsporozoite protein, ... (4 entities in total)
• Functional Keywords: malaria, csp, junction region, antibody, m43.149, immune system
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 6
• Total formula weight: 106384.07

Authors

Xu, K.,Kwong, P.D. (deposition date: 2021-07-09, release date: 2021-12-15, Last modification date: 2023-10-18)

• Primary citation: Kratochvil, S.,Shen, C.H.,Lin, Y.C.,Xu, K.,Nair, U.,Da Silva Pereira, L.,Tripathi, P.,Arnold, J.,Chuang, G.Y.,Melzi, E.,Schon, A.,Zhang, B.,Dillon, M.,Bonilla, B.,Flynn, B.J.,Kirsch, K.H.,Kisalu, N.K.,Kiyuka, P.K.,Liu, T.,Ou, L.,Pancera, M.,Rawi, R.,Reveiz, M.,Seignon, K.,Wang, L.T.,Waring, M.T.,Warner, J.,Yang, Y.,Francica, J.R.,Idris, A.H.,Seder, R.A.,Kwong, P.D.,Batista, F.D.; Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies.; Immunity, 54:2859-, 2021; PubMed: 34788599; DOI: 10.1016/j.immuni.2021.10.017

Experimental method

X-RAY DIFFRACTION (1.75 Å)