7RCT

Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor RMC-4550

7RCT の概要

• エントリーDOI: 10.2210/pdb7rct/pdb
• 分子名称: Tyrosine-protein phosphatase non-receptor type 11, {3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl}methanol, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: shp2 rmc-4550 phosphatase, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 121441.55

構造登録者

Seegar, T.C.M. (登録日: 2021-07-08, 公開日: 2021-09-01, 最終更新日: 2023-10-18)

• 主引用文献: Vemulapalli, V.,Donovan, K.A.,Seegar, T.C.M.,Rogers, J.M.,Bae, M.,Lumpkin, R.J.,Cao, R.,Henke, M.T.,Ray, S.S.,Fischer, E.S.,Cuny, G.D.,Blacklow, S.C.; Targeted Degradation of the Oncogenic Phosphatase SHP2.; Biochemistry, 60:2593-2609, 2021; PubMed: 34411482; DOI: 10.1021/acs.biochem.1c00377

実験手法

X-RAY DIFFRACTION (1.8 Å)