7RBT
cryo-EM structure of human Gastric inhibitory polypeptide receptor GIPR bound to tirzepatide
Summary for 7RBT
Entry DOI | 10.2210/pdb7rbt/pdb |
Related | 7RA3 |
EMDB information | 24401 |
Descriptor | Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Single-chain variable fragment 16, ... (8 entities in total) |
Functional Keywords | class b gpcr, glucagon-like peptide-1 receptor, g protein nucleotide exchange factor., membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 7 |
Total formula weight | 196452.59 |
Authors | Sun, B.,Kobilka, B.K.,Sloop, K.W.,Feng, D.,Kobilka, T.S. (deposition date: 2021-07-06, release date: 2022-04-13) |
Primary citation | Sun, B.,Willard, F.S.,Feng, D.,Alsina-Fernandez, J.,Chen, Q.,Vieth, M.,Ho, J.D.,Showalter, A.D.,Stutsman, C.,Ding, L.,Suter, T.M.,Dunbar, J.D.,Carpenter, J.W.,Mohammed, F.A.,Aihara, E.,Brown, R.A.,Bueno, A.B.,Emmerson, P.J.,Moyers, J.S.,Kobilka, T.S.,Coghlan, M.P.,Kobilka, B.K.,Sloop, K.W. Structural determinants of dual incretin receptor agonism by tirzepatide. Proc.Natl.Acad.Sci.USA, 119:e2116506119-e2116506119, 2022 Cited by PubMed: 35333651DOI: 10.1073/pnas.2116506119 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.08 Å) |
Structure validation
Download full validation report