7RBT
cryo-EM structure of human Gastric inhibitory polypeptide receptor GIPR bound to tirzepatide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 373 | 43385.2 | 1 | UniProt (P63092-2) Pfam (PF00503) UniProt (by SIFTS) (P63092) | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38534.1 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (Human) | Transducin beta chain 1 |
| 3 | C (E) | Single-chain variable fragment 16 | polymer | 297 | 31870.6 | 1 | Mus musculus | ||
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 5 | E (N) | nanobody 35 | polymer | 160 | 17352.5 | 1 | Lama glama | ||
| 6 | F (P) | Tirzepatide | polymer | 39 | 4072.5 | 1 | Homo sapiens | ||
| 7 | G (R) | Gastric inhibitory polypeptide receptor | polymer | 463 | 52871.8 | 1 | UniProt (P48546) Pfam (PF02793) Pfam (PF00002) | Homo sapiens (Human) | GIP-R,Glucose-dependent insulinotropic polypeptide receptor |
| 8 | H (R) | 2-fluoro-4-[(1R)-6-methoxy-1-methyl-2-{(1S)-1-[4-(propan-2-yl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinolin-5-yl]-6-[(2-methylpropyl)amino]phenol | non-polymer | 504.7 | 1 | Chemie (41Y) |
Sequence modifications
A: 26 - 394 (UniProt: P63092-2)
B: 2 - 340 (UniProt: P62873)
R: 22 - 466 (UniProt: P48546)
| PDB | External Database | Details |
|---|---|---|
| Met 8 | - | initiating methionine |
| Gly 9 | - | expression tag |
| Cys 10 | - | expression tag |
| Thr 11 | - | expression tag |
| Leu 12 | - | expression tag |
| Ser 13 | - | expression tag |
| Ala 14 | - | expression tag |
| Glu 15 | - | expression tag |
| Asp 16 | - | expression tag |
| Lys 17 | - | expression tag |
| Ala 18 | - | expression tag |
| Ala 19 | - | expression tag |
| Val 20 | - | expression tag |
| Glu 21 | - | expression tag |
| Arg 22 | - | expression tag |
| Ser 23 | - | expression tag |
| Lys 24 | - | expression tag |
| Met 25 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp 4 | - | expression tag |
| Tyr 5 | - | expression tag |
| Lys 6 | - | expression tag |
| Asp 7 | - | expression tag |
| Asp 8 | - | expression tag |
| Asp 9 | - | expression tag |
| Asp 10 | - | expression tag |
| Ala 11 | - | expression tag |
| Ala 12 | - | expression tag |
| Ala 13 | - | expression tag |
| Leu 14 | - | expression tag |
| Glu 15 | - | expression tag |
| Val 16 | - | expression tag |
| Leu 17 | - | expression tag |
| Phe 18 | - | expression tag |
| Gln 19 | - | expression tag |
| Gly 20 | - | expression tag |
| Pro 21 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 195947.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 504.7 | |
| All* | Total formula weight | 196452.6 |
