7R9T
Crystal structure of HPK1 in complex with compound 17
Summary for 7R9T
Entry DOI | 10.2210/pdb7r9t/pdb |
Descriptor | Hematopoietic progenitor kinase, 6-amino-3-[(1S,3R)-4'-chloro-3-hydroxy-1',2'-dihydrospiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridin]-5'-yl]-2-fluoro-N,N-dimethylbenzamide (3 entities in total) |
Functional Keywords | kinase, inhibitor, map4k1, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 67222.64 |
Authors | Wu, P.,Lehoux, I.,Wang, W. (deposition date: 2021-06-29, release date: 2022-01-05, Last modification date: 2023-10-18) |
Primary citation | Chan, B.K.,Seward, E.,Lainchbury, M.,Brewer, T.F.,An, L.,Blench, T.,Cartwright, M.W.,Chan, G.K.Y.,Choo, E.F.,Drummond, J.,Elliott, R.L.,Gancia, E.,Gazzard, L.,Hu, B.,Jones, G.E.,Luo, X.,Madin, A.,Malhotra, S.,Moffat, J.G.,Pang, J.,Salphati, L.,Sneeringer, C.J.,Stivala, C.E.,Wei, B.,Wang, W.,Wu, P.,Heffron, T.P. Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1). Acs Med.Chem.Lett., 13:84-91, 2022 Cited by PubMed: 35059127DOI: 10.1021/acsmedchemlett.1c00473 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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