7R8Y

Ancestral protein AncThEn of Phosphomethylpyrimidine kinases family

Summary for 7R8Y

• Entry DOI: 10.2210/pdb7r8y/pdb
• Descriptor: Phosphomethylpyrimidine Kinase, 4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE (2 entities in total)
• Functional Keywords: ancestral protein reconstruction, 5-phosphohydroxymethyl-2-methylpyrimidine kinase, phosphomethylpyrimidine kinases family, enzyme evolution, transferase
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 60952.37

Authors

Munoz, S.,Maturana, P.,Gonzalez-Ordenes, F.,Cea, P.,Castro-Fernandez, V. (deposition date: 2021-06-27, release date: 2022-06-29, Last modification date: 2024-08-21)

• Primary citation: Cea, P.A.,Perez, M.,Herrera, S.M.,Munoz, S.M.,Fuentes-Ugarte, N.,Coche-Miranda, J.,Maturana, P.,Guixe, V.,Castro-Fernandez, V.; Deciphering Structural Traits for Thermal and Kinetic Stability across Protein Family Evolution through Ancestral Sequence Reconstruction; Mol.Biol.Evol., 41:-, 2024; DOI: 10.1093/molbev/msae127

Experimental method

X-RAY DIFFRACTION (3.2 Å)