7R7P

Immature HIV-1 CACTD-SP1 lattice with Bevirimat (BVM) and Inositol hexakisphosphate (IP6)

Summary for 7R7P

• Entry DOI: 10.2210/pdb7r7p/pdb
• NMR Information: BMRB: 30929
• Descriptor: Gag polyprotein, INOSITOL HEXAKISPHOSPHATE, 3alpha-[(3-carboxy-3-methylbutanoyl)oxy]-8alpha,9beta,10alpha,13alpha,17alpha,19beta-lup-20(29)-en-28-oic acid (3 entities in total)
• Functional Keywords: hiv-1 capsid, maturation inhibitors, hiv-aids, protein binding
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 6
• Total formula weight: 67812.89

Authors

Sarkar, S.,Zadrozny, K.K.,Zadorozhnyi, R.,Russell, R.W.,Quinn, C.M.,Kleinpeter, A.,Ablan, S.,Meshkin, H.,Perilla, J.R.,Ganser-Pornillos, B.K.,Pornillos, O.,Freed, E.O.,Gronenborn, A.M.,Polenova, T. (deposition date: 2021-06-25, release date: 2023-02-15, Last modification date: 2023-03-22)

• Primary citation: Sarkar, S.,Zadrozny, K.K.,Zadorozhnyi, R.,Russell, R.W.,Quinn, C.M.,Kleinpeter, A.,Ablan, S.,Meshkin, H.,Perilla, J.R.,Freed, E.O.,Ganser-Pornillos, B.K.,Pornillos, O.,Gronenborn, A.M.,Polenova, T.; Structural basis of HIV-1 maturation inhibitor binding and activity.; Nat Commun, 14:1237-1237, 2023; PubMed: 36871077; DOI: 10.1038/s41467-023-36569-y

Experimental method

SOLID-STATE NMR