7R7K

Structure of Human Anaplastic Lymphoma Kinase Domain in complex with (4-[6-amino-5-[(1~{R})-1-[5-fluoro-2-(triazol-2-yl)phenyl]ethoxy]-3-pyridyl]isoindolin-1-one)

7R7K の概要

• エントリーDOI: 10.2210/pdb7r7k/pdb
• 分子名称: ALK tyrosine kinase receptor, 4-(6-amino-5-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyridin-3-yl)-2,3-dihydro-1H-isoindol-1-one (3 entities in total)
• 機能のキーワード: kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37339.79

構造登録者

McTigue, M. (登録日: 2021-06-24, 公開日: 2022-06-29, 最終更新日: 2023-10-18)

• 主引用文献: Shiba-Ishii, A.,Johnson, T.W.,Dagogo-Jack, I.,Mino-Kenudson, M.,Johnson, T.R.,Wei, P.,Weinrich, S.L.,McTigue, M.A.,Walcott, M.A.,Nguyen-Phuong, L.,Dionne, K.,Acker, A.,Kiedrowski, L.A.,Do, A.,Peterson, J.L.,Barth, J.L.,Yeap, B.Y.,Gainor, J.F.,Lin, J.J.,Yoda, S.,Hata, A.N.; Analysis of lorlatinib analogs reveals a roadmap for targeting diverse compound resistance mutations in ALK-positive lung cancer.; Nat Cancer, 3:710-722, 2022; PubMed: 35726063; DOI: 10.1038/s43018-022-00399-6

実験手法

X-RAY DIFFRACTION (1.831 Å)