7R78
cryo-EM structure of DNMT5 quaternary complex with hemimethylated DNA, AMP-PNP and SAH
Summary for 7R78
Entry DOI | 10.2210/pdb7r78/pdb |
Related | 7R76 7R77 |
EMDB information | 24292 24294 24295 |
Descriptor | DNA repair protein Rad8, DNA (5'-D(P*CP*AP*GP*(5CM)P*GP*CP*AP*T)-3'), DNA (5'-D(*TP*GP*CP*GP*CP*TP*GP*AP*CP*A)-3'), ... (7 entities in total) |
Functional Keywords | cytosine-5 methyltransferase, snf2 atpase, transferase, hemimethylated dna, atp, sam, transferase-dna complex, transferase/dna |
Biological source | Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) More |
Total number of polymer chains | 3 |
Total formula weight | 287220.90 |
Authors | Wang, J.,Patel, D.J. (deposition date: 2021-06-24, release date: 2022-02-23, Last modification date: 2024-06-05) |
Primary citation | Wang, J.,Catania, S.,Wang, C.,de la Cruz, M.J.,Rao, B.,Madhani, H.D.,Patel, D.J. Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance. Mol.Cell, 82:1186-1198.e6, 2022 Cited by PubMed: 35202575DOI: 10.1016/j.molcel.2022.01.028 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.5 Å) |
Structure validation
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