7R3Z

Tankyrase 2 catalytic domain in complex with OUL40

Summary for 7R3Z

Entry DOI	10.2210/pdb7r3z/pdb
Descriptor	Poly [ADP-ribose] polymerase tankyrase-2, 6-methyl-[1,2,4]triazolo[3,4-b][1,3]benzothiazole, SULFATE ION, ... (7 entities in total)
Functional Keywords	human poly-adp-ribose transferase, inhibitor, complex, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	50677.82
Authors	Murthy, S.,Venkannagari, H.,Maksimainen, M.M.,Lehtio, L. (deposition date: 2022-02-08, release date: 2023-01-25, Last modification date: 2024-02-07)
Primary citation	Murthy, S.,Nizi, M.G.,Maksimainen, M.M.,Massari, S.,Alaviuhkola, J.,Lippok, B.E.,Vagaggini, C.,Sowa, S.T.,Galera-Prat, A.,Ashok, Y.,Venkannagari, H.,Prunskaite-Hyyrylainen, R.,Dreassi, E.,Luscher, B.,Korn, P.,Tabarrini, O.,Lehtio, L. [1,2,4]Triazolo[3,4- b ]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. J.Med.Chem., 66:1301-1320, 2023 Cited by PubMed: 36598465 DOI: 10.1021/acs.jmedchem.2c01460 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation