7R3X
The crystal structure of the L439V variant of Pol2CORE in complex with DNA and an incoming nucleotide
Summary for 7R3X
Entry DOI | 10.2210/pdb7r3x/pdb |
Descriptor | DNA polymerase epsilon catalytic subunit A, DNA Primer, DNA Template, ... (7 entities in total) |
Functional Keywords | protein-dna complex, dna binding protein |
Biological source | Saccharomyces cerevisiae (baker's yeast) More |
Total number of polymer chains | 3 |
Total formula weight | 145408.75 |
Authors | Barbari, S.R.,Beach, A.K.,Markgren, J.G.,Parkash, V.,Johansson, E.,Shcherbakova, P.V. (deposition date: 2022-02-08, release date: 2022-07-27, Last modification date: 2024-01-31) |
Primary citation | Barbari, S.R.,Beach, A.K.,Markgren, J.G.,Parkash, V.,Moore, E.A.,Johansson, E.,Shcherbakova, P.V. Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ε variants at low dNTP levels. Nucleic Acids Res., 50:8023-8040, 2022 Cited by PubMed: 35822874DOI: 10.1093/nar/gkac602 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.46 Å) |
Structure validation
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