7R3X

The crystal structure of the L439V variant of Pol2CORE in complex with DNA and an incoming nucleotide

7R3X の概要

• エントリーDOI: 10.2210/pdb7r3x/pdb
• 分子名称: DNA polymerase epsilon catalytic subunit A, DNA Primer, DNA Template, ... (7 entities in total)
• 機能のキーワード: protein-dna complex, dna binding protein
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 145408.75

構造登録者

Barbari, S.R.,Beach, A.K.,Markgren, J.G.,Parkash, V.,Johansson, E.,Shcherbakova, P.V. (登録日: 2022-02-08, 公開日: 2022-07-27, 最終更新日: 2024-01-31)

• 主引用文献: Barbari, S.R.,Beach, A.K.,Markgren, J.G.,Parkash, V.,Moore, E.A.,Johansson, E.,Shcherbakova, P.V.; Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ε variants at low dNTP levels.; Nucleic Acids Res., 50:8023-8040, 2022; PubMed: 35822874; DOI: 10.1093/nar/gkac602

実験手法

X-RAY DIFFRACTION (2.46 Å)