7R2V

Structure of nsp14 from SARS-CoV-2 in complex with SAH

7R2V の概要

• エントリーDOI: 10.2210/pdb7r2v/pdb
• 分子名称: Proofreading exoribonuclease nsp14, S-ADENOSYL-L-HOMOCYSTEINE, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
• 機能のキーワード: nsp14, complex, sah, sars-cov-2, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 120617.99

構造登録者

Czarna, A.,Plewka, J.,Kresik, L.,Matsuda, A.,Abdulkarim, K.,Robinson, C.,OByrne, S.,Cunningham, F.,Georgiou, I.,Pachota, M.,Popowicz, G.M.,Wyatt, P.G.,Dubin, G.,Pyrc, K. (登録日: 2022-02-06, 公開日: 2022-03-09, 最終更新日: 2024-01-31)

• 主引用文献: Czarna, A.,Plewka, J.,Kresik, L.,Matsuda, A.,Karim, A.,Robinson, C.,O'Byrne, S.,Cunningham, F.,Georgiou, I.,Wilk, P.,Pachota, M.,Popowicz, G.,Wyatt, P.G.,Dubin, G.,Pyrc, K.; Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity.; Structure, 30:1050-1054.e2, 2022; PubMed: 35609600; DOI: 10.1016/j.str.2022.04.014

実験手法

X-RAY DIFFRACTION (2.53 Å)