7R2J

Human Cyclophilin D in complex with N-(4-aminophenyl)-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide

Summary for 7R2J

• Entry DOI: 10.2210/pdb7r2j/pdb
• Descriptor: Peptidyl-prolyl cis-trans isomerase F, mitochondrial, N-(4-aminophenyl)-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total)
• Functional Keywords: cyclophilin d ppiase, isomerase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 18144.74

Authors

Silva, D.O.,Graedler, U.,Bandeiras, T.M. (deposition date: 2022-02-04, release date: 2023-02-15, Last modification date: 2026-04-01)

• Primary citation: Silva, D.O.,Freitas, M.C.,Malta, C.F.,Martins, M.T.,Sousa, P.M.,Matias, P.M.,Schwarz, D.,Ventura, M.R.,Gradler, U.,Bandeiras, T.M.; Structure-based design of pyrazole derivatives targeting the human Cyclophilin D binding site; Int.J.Biol.Macromol., :151496-, 2026; DOI: 10.1016/j.ijbiomac.2026.151496

Experimental method

X-RAY DIFFRACTION (1.26 Å)