7R2I

Human Cyclophilin D in complex with fragment

Summary for 7R2I

Entry DOI	10.2210/pdb7r2i/pdb
Descriptor	Peptidyl-prolyl cis-trans isomerase F, mitochondrial, DIMETHYL SULFOXIDE, ethyl 7-methyl-2-oxidanylidene-1,3-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate, ... (5 entities in total)
Functional Keywords	cyclophilin d ppiase, isomerase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	18320.95
Authors	Silva, D.O.,Graedler, U.,Bandeiras, T.M. (deposition date: 2022-02-04, release date: 2023-02-15, Last modification date: 2026-04-01)
Primary citation	Silva, D.O.,Freitas, M.C.,Malta, C.F.,Martins, M.T.,Sousa, P.M.,Matias, P.M.,Schwarz, D.,Ventura, M.R.,Gradler, U.,Bandeiras, T.M. Structure-based design of pyrazole derivatives targeting the human Cyclophilin D binding site Int.J.Biol.Macromol., :151496-, 2026 Cited by DOI: 10.1016/j.ijbiomac.2026.151496 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.31 Å)

Structure validation