7R1T
Crystal structure of SARS-CoV-2 nsp10/nsp16 in complex with the SS148 inhibitor
Summary for 7R1T
Entry DOI | 10.2210/pdb7r1t/pdb |
Descriptor | 2'-O-methyltransferase nsp16, Non-structural protein 10, (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, ... (7 entities in total) |
Functional Keywords | methyltransferase, nsp10, nsp16, inhibitor, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 More |
Total number of polymer chains | 2 |
Total formula weight | 47536.95 |
Authors | Klima, M.,Boura, E.,Li, F.,Yazdi, A.K.,Vedadi, M. (deposition date: 2022-02-03, release date: 2022-06-29, Last modification date: 2024-01-31) |
Primary citation | Klima, M.,Khalili Yazdi, A.,Li, F.,Chau, I.,Hajian, T.,Bolotokova, A.,Kaniskan, H.U.,Han, Y.,Wang, K.,Li, D.,Luo, M.,Jin, J.,Boura, E.,Vedadi, M. Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16. Protein Sci., 31:e4395-e4395, 2022 Cited by PubMed: 36040262DOI: 10.1002/pro.4395 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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