7R1T

Crystal structure of SARS-CoV-2 nsp10/nsp16 in complex with the SS148 inhibitor

7R1T の概要

• エントリーDOI: 10.2210/pdb7r1t/pdb
• 分子名称: 2'-O-methyltransferase nsp16, Non-structural protein 10, (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, ... (7 entities in total)
• 機能のキーワード: methyltransferase, nsp10, nsp16, inhibitor, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47536.95

構造登録者

Klima, M.,Boura, E.,Li, F.,Yazdi, A.K.,Vedadi, M. (登録日: 2022-02-03, 公開日: 2022-06-29, 最終更新日: 2024-01-31)

• 主引用文献: Klima, M.,Khalili Yazdi, A.,Li, F.,Chau, I.,Hajian, T.,Bolotokova, A.,Kaniskan, H.U.,Han, Y.,Wang, K.,Li, D.,Luo, M.,Jin, J.,Boura, E.,Vedadi, M.; Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16.; Protein Sci., 31:e4395-e4395, 2022; PubMed: 36040262; DOI: 10.1002/pro.4395

実験手法

X-RAY DIFFRACTION (2.7 Å)