7QX9
BAZ2A bromodomain in complex with acetylpyrrole derivative compound 65
Summary for 7QX9
| Entry DOI | 10.2210/pdb7qx9/pdb |
| Related | 7QVU 7QWF 7QWU 7QWY 7QX2 |
| Descriptor | Bromodomain adjacent to zinc finger domain protein 2A, 3-[[4-(4-ethanoyl-3,5-dimethyl-1~{H}-pyrrol-2-yl)-1,3-thiazol-2-yl]methyl]imidazolidine-2,4-dione (3 entities in total) |
| Functional Keywords | four helical bundle, transcription |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 12696.25 |
| Authors | Dalle Vedove, A.,Cazzanelli, G.,Caflisch, A.,Lolli, G. (deposition date: 2022-01-26, release date: 2022-09-28, Last modification date: 2024-01-31) |
| Primary citation | Dalle Vedove, A.,Cazzanelli, G.,Batiste, L.,Marchand, J.R.,Spiliotopoulos, D.,Corsi, J.,D'Agostino, V.G.,Caflisch, A.,Lolli, G. Identification of a BAZ2A-Bromodomain Hit Compound by Fragment Growing. Acs Med.Chem.Lett., 13:1434-1443, 2022 Cited by PubMed: 36105334DOI: 10.1021/acsmedchemlett.2c00173 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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