7QVV

BAZ2A bromodomain in complex with pyridone derivative fragment 36

Summary for 7QVV

Entry DOI	10.2210/pdb7qvv/pdb
Related	7QVT 7QVU
Descriptor	Bromodomain adjacent to zinc finger domain protein 2A, 5-(4-azanylpiperidin-1-yl)carbonyl-1~{H}-pyridin-2-one (3 entities in total)
Functional Keywords	four helical bundle, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	12602.17
Authors	Dalle Vedove, A.,Cazzanelli, G.,Caflisch, A.,Lolli, G. (deposition date: 2022-01-23, release date: 2022-09-28, Last modification date: 2024-01-31)
Primary citation	Dalle Vedove, A.,Cazzanelli, G.,Batiste, L.,Marchand, J.R.,Spiliotopoulos, D.,Corsi, J.,D'Agostino, V.G.,Caflisch, A.,Lolli, G. Identification of a BAZ2A-Bromodomain Hit Compound by Fragment Growing. Acs Med.Chem.Lett., 13:1434-1443, 2022 Cited by PubMed: 36105334 DOI: 10.1021/acsmedchemlett.2c00173 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.601 Å)

Structure validation