7QVM

Human Oxytocin receptor (OTR) oxytocin Gq chimera (mGoqi) complex

7QVM の概要

• エントリーDOI: 10.2210/pdb7qvm/pdb
• EMDBエントリー: 14180
• 分子名称: Guanine nucleotide-binding protein G(o) subunit alpha,cDNA FLJ31446 fis, clone NT2NE2000909, highly similar to Guanine nucleotide-binding protein G(o) subunit alpha 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• 機能のキーワード: gpcr, otr, g protein, ot, scfv16, mgoqi, oxytocin, membrane protein, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 140063.41

構造登録者

Waltenspuhl, Y.,Ehrenmann, J.,Vacca, S.,Thom, C.,Medalia, O.,Pluckthun, A. (登録日: 2022-01-21, 公開日: 2022-08-10, 最終更新日: 2024-10-23)

主引用文献

Waltenspuhl, Y.,Ehrenmann, J.,Vacca, S.,Thom, C.,Medalia, O.,Pluckthun, A.
Structural basis for the activation and ligand recognition of the human oxytocin receptor.
Nat Commun, 13:4153-4153, 2022

PubMed Abstract: The small cyclic neuropeptide hormone oxytocin (OT) and its cognate receptor play a central role in the regulation of social behaviour and sexual reproduction. Here we report the single-particle cryo-electron microscopy structure of the active oxytocin receptor (OTR) in complex with its cognate ligand oxytocin. Our structure provides high-resolution insights into the OT binding mode, the OTR activation mechanism as well as the subtype specificity within the oxytocin/vasopressin receptor family.

PubMed: 35851571
DOI: 10.1038/s41467-022-31325-0

実験手法

ELECTRON MICROSCOPY (3.25 Å)