7QVC
TMEM106B filaments with Fold I from Alzheimer's disease (case 1)
Summary for 7QVC
Entry DOI | 10.2210/pdb7qvc/pdb |
EMDB information | 14174 |
Descriptor | Transmembrane protein 106B (1 entity in total) |
Functional Keywords | amyloid, neurodegeneration, filament, tmem106b, protein fibril |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 93426.88 |
Authors | Lovestam, S.,Schweighauser, M.,Scheres, S.H.W. (deposition date: 2022-01-21, release date: 2022-03-09, Last modification date: 2022-05-25) |
Primary citation | Schweighauser, M.,Arseni, D.,Bacioglu, M.,Huang, M.,Lovestam, S.,Shi, Y.,Yang, Y.,Zhang, W.,Kotecha, A.,Garringer, H.J.,Vidal, R.,Hallinan, G.I.,Newell, K.L.,Tarutani, A.,Murayama, S.,Miyazaki, M.,Saito, Y.,Yoshida, M.,Hasegawa, K.,Lashley, T.,Revesz, T.,Kovacs, G.G.,van Swieten, J.,Takao, M.,Hasegawa, M.,Ghetti, B.,Spillantini, M.G.,Ryskeldi-Falcon, B.,Murzin, A.G.,Goedert, M.,Scheres, S.H.W. Age-dependent formation of TMEM106B amyloid filaments in human brains. Nature, 605:310-314, 2022 Cited by PubMed: 35344985DOI: 10.1038/s41586-022-04650-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.64 Å) |
Structure validation
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