7QUN

CryoEM structure of mammalian AAP in complex with Meropenem

Summary for 7QUN

Entry DOI	10.2210/pdb7qun/pdb
Related	7px8
EMDB information	14149
Descriptor	Acylamino-acid-releasing enzyme, (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid (2 entities in total)
Functional Keywords	inhibitor, complex, acylaminoacyl-peptidase, meropenem, carbapenem, acylpeptide hydrolase, hydrolase
Biological source	Sus scrofa domesticus (domestic pig)
Total number of polymer chains	4
Total formula weight	326839.48
Authors	Kiss-Szeman, A.J.,Harmat, V.,Straner, P.,Jakli, I.,Menyhard, K.D.,Masiulis, S.,Perczel, A. (deposition date: 2022-01-18, release date: 2022-11-16, Last modification date: 2023-02-01)
Primary citation	Kiss-Szeman, A.J.,Takacs, L.,Orgovan, Z.,Straner, P.,Jakli, I.,Schlosser, G.,Masiulis, S.,Harmat, V.,Menyhard, D.K.,Perczel, A. A carbapenem antibiotic inhibiting a mammalian serine protease: structure of the acylaminoacyl peptidase-meropenem complex. Chem Sci, 13:14264-14276, 2022 Cited by PubMed: 36545146 DOI: 10.1039/d2sc05520a PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.1 Å)

Structure validation