7QTQ

Structure of Native, iodinated bovine thyroglobulin solved on strepavidin affinity grids.

7QTQ の概要

• エントリーDOI: 10.2210/pdb7qtq/pdb
• EMDBエントリー: 14145
• 分子名称: Thyroglobulin, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: thyroglobulin, thyroid hormone, iodine, precursor, hormone
• 由来する生物種: Bos taurus (cattle)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 612761.51

構造登録者

Marechal, N.,Weitz, J.C.,Serrano, B.P.,Zhang, X. (登録日: 2022-01-15, 公開日: 2022-05-04, 最終更新日: 2023-11-15)

主引用文献

Marechal, N.,Serrano, B.P.,Zhang, X.,Weitz, C.J.
Formation of thyroid hormone revealed by a cryo-EM structure of native bovine thyroglobulin.
Nat Commun, 13:2380-2380, 2022

PubMed Abstract: Thyroid hormones are essential regulators of metabolism, development, and growth. They are formed from pairs of iodinated tyrosine residues within the precursor thyroglobulin (TG), a 660-kDa homodimer of the thyroid gland, by an oxidative coupling reaction. Tyrosine pairs that give rise to thyroid hormones have been assigned within the structure of human TG, but the process of hormone formation is poorly understood. Here we report a ~3.3-Å cryo-EM structure of native bovine TG with nascent thyroid hormone formed at one of the predicted hormonogenic sites. Local structural rearrangements provide insight into mechanisms underlying thyroid hormone formation and stabilization.

PubMed: 35501346
DOI: 10.1038/s41467-022-30082-4

実験手法

ELECTRON MICROSCOPY (3.3 Å)