7QNE

Cryo-EM structure of human full-length synaptic alpha1beta3gamma2 GABA(A)R in complex with Ro15-4513 and megabody Mb38

Summary for 7QNE

• Entry DOI: 10.2210/pdb7qne/pdb
• EMDB information: 14076
• Descriptor: GABA(A) receptor subunit alpha-1, N-OCTANE, DECANE, ... (14 entities in total)
• Functional Keywords: pentameric ligand-gated ion channel, neurotransmitter receptor, gaba receptor, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 290772.29

Authors

Sente, A.,Desai, R.,Naydenova, K.,Malinauskas, T.,Jounaidi, Y.,Miehling, J.,Zhou, X.,Masiulis, S.,Hardwick, S.W.,Chirgadze, D.Y.,Miller, K.W.,Aricescu, A.R. (deposition date: 2021-12-20, release date: 2022-04-13, Last modification date: 2022-05-04)

• Primary citation: Sente, A.,Desai, R.,Naydenova, K.,Malinauskas, T.,Jounaidi, Y.,Miehling, J.,Zhou, X.,Masiulis, S.,Hardwick, S.W.,Chirgadze, D.Y.,Miller, K.W.,Aricescu, A.R.; Differential assembly diversifies GABA A receptor structures and signalling.; Nature, 604:190-194, 2022; PubMed: 35355020; DOI: 10.1038/s41586-022-04517-3

Experimental method

ELECTRON MICROSCOPY (2.7 Å)