7QIF

Crystal structure of SARS-CoV-2 NSP14 in complex with 7MeGpppG.

7QIF の概要

• エントリーDOI: 10.2210/pdb7qif/pdb
• 分子名称: Proofreading exoribonuclease nsp14, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, ZINC ION, ... (5 entities in total)
• 機能のキーワード: nsp14, sars-cov-2, nuclease, methyltransferase, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 60723.78

構造登録者

Newman, J.A.,Imprachim, N.,Yosaatmadja, Y.,Gileadi, O. (登録日: 2021-12-14, 公開日: 2022-02-02, 最終更新日: 2024-02-07)

• 主引用文献: Imprachim, N.,Yosaatmadja, Y.,Newman, J.A.; Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development.; Nucleic Acids Res., 51:475-487, 2023; PubMed: 36546776; DOI: 10.1093/nar/gkac1207

実験手法

X-RAY DIFFRACTION (2.53 Å)