7QIE
Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an allosteric inhibitor
Summary for 7QIE
Entry DOI | 10.2210/pdb7qie/pdb |
Descriptor | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma, 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-(pyridin-2-ylmethyl)pyrrolo[3,2-d]pyrimidin-4-amine (3 entities in total) |
Functional Keywords | allosteric binding, lipid kinase, non-atp-competitive inhibitor, phosphatidylinositol 5-phosphate, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 169501.48 |
Authors | Howard, T.D.,Ogg, D.T. (deposition date: 2021-12-14, release date: 2022-05-18, Last modification date: 2024-01-31) |
Primary citation | Boffey, H.K.,Rooney, T.P.C.,Willems, H.M.G.,Edwards, S.,Green, C.,Howard, T.,Ogg, D.,Romero, T.,Scott, D.E.,Winpenny, D.,Duce, J.,Skidmore, J.,Clarke, J.H.,Andrews, S.P. Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase gamma Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode. J.Med.Chem., 65:3359-3370, 2022 Cited by PubMed: 35148092DOI: 10.1021/acs.jmedchem.1c01819 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.39 Å) |
Structure validation
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