7QIE

Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an allosteric inhibitor

7QIE の概要

• エントリーDOI: 10.2210/pdb7qie/pdb
• 分子名称: Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma, 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-(pyridin-2-ylmethyl)pyrrolo[3,2-d]pyrimidin-4-amine (3 entities in total)
• 機能のキーワード: allosteric binding, lipid kinase, non-atp-competitive inhibitor, phosphatidylinositol 5-phosphate, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 169501.48

構造登録者

Howard, T.D.,Ogg, D.T. (登録日: 2021-12-14, 公開日: 2022-05-18, 最終更新日: 2024-01-31)

• 主引用文献: Boffey, H.K.,Rooney, T.P.C.,Willems, H.M.G.,Edwards, S.,Green, C.,Howard, T.,Ogg, D.,Romero, T.,Scott, D.E.,Winpenny, D.,Duce, J.,Skidmore, J.,Clarke, J.H.,Andrews, S.P.; Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase gamma Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.; J.Med.Chem., 65:3359-3370, 2022; PubMed: 35148092; DOI: 10.1021/acs.jmedchem.1c01819

実験手法

X-RAY DIFFRACTION (2.39 Å)