7QI1
Crystal structure of human 14-3-3 protein beta in complex with CFTR peptide pS753pS768 and PPI stabilizer CY007424
Summary for 7QI1
Entry DOI | 10.2210/pdb7qi1/pdb |
Descriptor | 14-3-3 protein theta, Cystic fibrosis transmembrane conductance regulator, ARGININE, ... (7 entities in total) |
Functional Keywords | ppi stabilization, cystic fibrosis, protein transport |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 116439.39 |
Authors | Stevers, L.M.,Ottmann, C. (deposition date: 2021-12-14, release date: 2022-05-25, Last modification date: 2024-01-31) |
Primary citation | Stevers, L.M.,Wolter, M.,Carlile, G.W.,Macdonald, D.,Richard, L.,Gielkens, F.,Hanrahan, J.W.,Thomas, D.Y.,Chakka, S.K.,Peterson, M.L.,Thomas, H.,Brunsveld, L.,Ottmann, C. Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR. Nat Commun, 13:3586-3586, 2022 Cited by PubMed: 35739107DOI: 10.1038/s41467-022-31206-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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