7QI1

Crystal structure of human 14-3-3 protein beta in complex with CFTR peptide pS753pS768 and PPI stabilizer CY007424

7QI1 の概要

• エントリーDOI: 10.2210/pdb7qi1/pdb
• 分子名称: 14-3-3 protein theta, Cystic fibrosis transmembrane conductance regulator, ARGININE, ... (7 entities in total)
• 機能のキーワード: ppi stabilization, cystic fibrosis, protein transport
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 116439.39

構造登録者

Stevers, L.M.,Ottmann, C. (登録日: 2021-12-14, 公開日: 2022-05-25, 最終更新日: 2024-01-31)

• 主引用文献: Stevers, L.M.,Wolter, M.,Carlile, G.W.,Macdonald, D.,Richard, L.,Gielkens, F.,Hanrahan, J.W.,Thomas, D.Y.,Chakka, S.K.,Peterson, M.L.,Thomas, H.,Brunsveld, L.,Ottmann, C.; Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR.; Nat Commun, 13:3586-3586, 2022; PubMed: 35739107; DOI: 10.1038/s41467-022-31206-6

実験手法

X-RAY DIFFRACTION (1.76 Å)