7QHP

Structure of I-Ag7 with a bound hybrid insulin peptide

Summary for 7QHP

• Entry DOI: 10.2210/pdb7qhp/pdb
• Descriptor: H-2 class II histocompatibility antigen, A-D alpha chain, Murine MHC class II I-A beta g7, Insulin-1, ... (7 entities in total)
• Functional Keywords: diabetes, mhc class ii, hybrid insulin peptide, autoimmune disease, immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 3
• Total formula weight: 51062.61

Authors

Lopez-Sagaseta, J.,Erausquin, E. (deposition date: 2021-12-13, release date: 2022-07-20, Last modification date: 2024-01-31)

• Primary citation: Erausquin, E.,Serra, P.,Parras, D.,Santamaria, P.,Lopez-Sagaseta, J.; Structural plasticity in I-A g7 links autoreactivity to hybrid insulin peptides in type I diabetes.; Front Immunol, 13:924311-924311, 2022; PubMed: 35967292; DOI: 10.3389/fimmu.2022.924311

Experimental method

X-RAY DIFFRACTION (1.82 Å)