7QHP
Structure of I-Ag7 with a bound hybrid insulin peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | H-2 class II histocompatibility antigen, A-D alpha chain | polymer | 202 | 23027.7 | 1 | UniProt (P04228) Pfam (PF00993) Pfam (PF07654) In PDB | Mus musculus (house mouse) | |
| 2 | B | Murine MHC class II I-A beta g7 | polymer | 230 | 26263.1 | 1 | Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (Q31135) In PDB | Mus musculus (house mouse) | |
| 3 | T | Insulin-1 | polymer | 13 | 1445.6 | 1 | UniProt (P01325) In PDB | Mus musculus (house mouse) | |
| 4 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | B | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | B | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 7 | water | water | 18.0 | 295 | Chemie (HOH) |
Sequence modifications
A: -1 - 193 (UniProt: P04228)
T: -1 - 11 (UniProt: P01325)
| PDB | External Database | Details |
|---|---|---|
| Cys 74 | Ile 99 | engineered mutation |
| Ser 194 | - | expression tag |
| Leu 195 | - | expression tag |
| Glu 196 | - | expression tag |
| Val 197 | - | expression tag |
| Leu 198 | - | expression tag |
| Phe 199 | - | expression tag |
| Gln 200 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 7 | Ala 83 | conflict |
| Asp 8 | Arg 84 | conflict |
| Asp 9 | Gln 85 | conflict |
| Pro 10 | Lys 86 | conflict |
| Cys 11 | Arg 87 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 50736.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 326.2 | |
| All* | Total formula weight | 51062.6 |
