7QHG

LIM domain kinase 2 (LIMK2) in complex with TH-470

Summary for 7QHG

Entry DOI	10.2210/pdb7qhg/pdb
Descriptor	LIM domain kinase 2, 2-(2-methylpropanoylamino)-~{N}-[2-[(phenylmethyl)-[4-(phenylsulfamoyl)phenyl]carbonyl-amino]ethyl]-1,3-thiazole-5-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	kinase, type-2 inhibitor, actin dynamics, cfl-1, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	71121.21
Authors	Mathea, S.,Salah, E.,Hanke, T.,Knapp, S. (deposition date: 2021-12-12, release date: 2021-12-22, Last modification date: 2024-01-31)
Primary citation	Hanke, T.,Mathea, S.,Woortman, J.,Salah, E.,Berger, B.T.,Tumber, A.,Kashima, R.,Hata, A.,Kuster, B.,Muller, S.,Knapp, S. Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes. J.Med.Chem., 65:13264-13287, 2022 Cited by PubMed: 36136092 DOI: 10.1021/acs.jmedchem.2c01106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation