7QH1

Discovery and development of a novel inhaled antivirulence therapy for the treatment of Pseudomonas aeruginosa infections in patients with chronic respiratory disease

Summary for 7QH1

• Entry DOI: 10.2210/pdb7qh1/pdb
• Descriptor: Keratinase KP2, ZINC ION, 2-[2-[[5-[3-[bis(2-hydroxyethyl)-methyl-$l^{4}-azanyl]propoxy]-6-methoxy-1,3-benzothiazol-2-yl]methylcarbamoyl]-5,6-bis(fluoranyl)-1,3-dihydroinden-2-yl]ethanoic acid, ... (5 entities in total)
• Functional Keywords: pseudomonas aeruginosa, respiratory disease, hydrolase
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 4
• Total formula weight: 135719.08

Authors

Leonard, P.M.,Davies, D.,Pallin, T.D. (deposition date: 2021-12-10, release date: 2022-12-21, Last modification date: 2024-02-07)

• Primary citation: Everett, M.J.,Davies, D.T.,Leiris, S.,Sprynski, N.,Llanos, A.,Castandet, J.M.,Lozano, C.,LaRock, C.N.,LaRock, D.L.,Corsica, G.,Docquier, J.D.,Pallin, T.D.,Cridland, A.,Blench, T.,Zalacain, M.,Lemonnier, M.; Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1 beta in Cellular and Animal Infection Models.; Acs Infect Dis., 9:270-282, 2023; PubMed: 36669138; DOI: 10.1021/acsinfecdis.2c00418

Experimental method

X-RAY DIFFRACTION (2.74 Å)