7QH1

Discovery and development of a novel inhaled antivirulence therapy for the treatment of Pseudomonas aeruginosa infections in patients with chronic respiratory disease

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
B	0004222	molecular_function	metalloendopeptidase activity
B	0006508	biological_process	proteolysis
C	0004222	molecular_function	metalloendopeptidase activity
C	0006508	biological_process	proteolysis
D	0004222	molecular_function	metalloendopeptidase activity
D	0006508	biological_process	proteolysis

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEVSHGF

Chain	Residue	Details
A	VAL137-PHE146

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:1899664

Chain	Residue	Details
A	GLU141
B	GLU141
C	GLU141
D	GLU141

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:1899664

Chain	Residue	Details
A	HIS223
B	HIS223
C	HIS223
D	HIS223

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site_id	SWS_FT_FI3
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269|PubMed:1899664, ECO:0000269|Ref.16, ECO:0000269|Ref.17

Chain	Residue	Details
A	ASP136
B	HIS140
B	HIS144
B	GLU164
B	GLU172
B	GLU175
B	ASP183
B	LEU185
C	ASP136
C	HIS140
C	HIS144
A	HIS140
C	GLU164
C	GLU172
C	GLU175
C	ASP183
C	LEU185
D	ASP136
D	HIS140
D	HIS144
D	GLU164
D	GLU172
A	HIS144
D	GLU175
D	ASP183
D	LEU185
A	GLU164
A	GLU172
A	GLU175
A	ASP183
A	LEU185
B	ASP136

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