7QGV

Solid-state NMR structure of Teixobactin-Lipid II.

Summary for 7QGV

• Entry DOI: 10.2210/pdb7qgv/pdb
• NMR Information: BMRB: 50938
• Related PRD ID: PRD_002268 PRD_002384
• Descriptor: Teixobactin, Lipid II, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-N-acetyl-alpha-muramic acid, ... (5 entities in total)
• Functional Keywords: antimicrobial, beta-sheet, membrane deformation, antibiotic
• Biological source: Eleftheria terrae; More
• Total number of polymer chains: 8
• Total formula weight: 10659.38

Authors

Weingarth, M.H.,Shukla, R. (deposition date: 2021-12-10, release date: 2022-08-03, Last modification date: 2023-11-15)

• Primary citation: Shukla, R.,Lavore, F.,Maity, S.,Derks, M.G.N.,Jones, C.R.,Vermeulen, B.J.A.,Melcrova, A.,Morris, M.A.,Becker, L.M.,Wang, X.,Kumar, R.,Medeiros-Silva, J.,van Beekveld, R.A.M.,Bonvin, A.M.J.J.,Lorent, J.H.,Lelli, M.,Nowick, J.S.,MacGillavry, H.D.,Peoples, A.J.,Spoering, A.L.,Ling, L.L.,Hughes, D.E.,Roos, W.H.,Breukink, E.,Lewis, K.,Weingarth, M.; Teixobactin kills bacteria by a two-pronged attack on the cell envelope.; Nature, 608:390-396, 2022; PubMed: 35922513; DOI: 10.1038/s41586-022-05019-y

Experimental method

SOLID-STATE NMR