7QGI

Crystal structure of SARS-CoV-2 NSP14 in the absence of NSP10

7QGI の概要

• エントリーDOI: 10.2210/pdb7qgi/pdb
• 分子名称: Proofreading exoribonuclease nsp14, ZINC ION, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: nuclease, methyltransferase, sars-cov-2, nsp14, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 59920.34

構造登録者

Newman, J.A.,Imprachim, N.,Yosaatmadja, Y.,Gileadi, O. (登録日: 2021-12-08, 公開日: 2022-01-26, 最終更新日: 2024-02-07)

• 主引用文献: Imprachim, N.,Yosaatmadja, Y.,Newman, J.A.; Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development.; Nucleic Acids Res., 51:475-487, 2023; PubMed: 36546776; DOI: 10.1093/nar/gkac1207

実験手法

X-RAY DIFFRACTION (1.65 Å)