7QDG

SARS-CoV-2 S protein S:A222V + S:D614G mutant 1-up

7QDG の概要

• エントリーDOI: 10.2210/pdb7qdg/pdb
• EMDBエントリー: 13916
• 分子名称: Spike glycoprotein,Fibritin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: sars-cov-2, s protein, s:a222v + s:d614g mutant, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 426990.81

構造登録者

Ginex, T.,Marco-Marin, C.,Wieczor, M.,Mata, C.P.,Krieger, J.,Lopez-Redondo, M.L.,Frances-Gomez, C.,Ruiz-Rodriguez, P.,Melero, R.,Sanchez-Sorzano, C.O.,Martinez, M.,Gougeard, N.,Forcada-Nadal, A.,Zamora-Caballero, S.,Gozalbo-Rovira, R.,Sanz-Frasquet, C.,Bravo, J.,Rubio, V.,Marina, A.,Geller, R.,Comas, I.,Gil, C.,Coscolla, M.,Orozco, M.,LLacer, J.L.,Carazo, J.M. (登録日: 2021-11-27, 公開日: 2022-05-25, 最終更新日: 2024-10-16)

主引用文献

Ginex, T.,Marco-Marin, C.,Wieczor, M.,Mata, C.P.,Krieger, J.,Ruiz-Rodriguez, P.,Lopez-Redondo, M.L.,Frances-Gomez, C.,Melero, R.,Sanchez-Sorzano, C.O.,Martinez, M.,Gougeard, N.,Forcada-Nadal, A.,Zamora-Caballero, S.,Gozalbo-Rovira, R.,Sanz-Frasquet, C.,Arranz, R.,Bravo, J.,Rubio, V.,Marina, A.,Geller, R.,Comas, I.,Gil, C.,Coscolla, M.,Orozco, M.,Llacer, J.L.,Carazo, J.M.
The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation.
Plos Pathog., 18:e1010631-e1010631, 2022

PubMed Abstract: The S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific effect on viral infection. We report combined serological, functional, structural and computational studies characterizing the impact of this mutation. Our results reveal that S:A222V promotes an increased RBD opening and slightly increases ACE2 binding as compared to the parent S:D614G clade. Finally, S:A222V does not reduce sera neutralization capacity, suggesting it does not affect vaccine effectiveness.

PubMed: 35816514
DOI: 10.1371/journal.ppat.1010631

実験手法

ELECTRON MICROSCOPY (3.4 Å)