7QCK

Structure of SARS-CoV-2 Papain-like Protease bound to N-(2,5-dihydroxybenzylidene)-thiosemicarbazone

Summary for 7QCK

• Entry DOI: 10.2210/pdb7qck/pdb
• Descriptor: Papain-like protease nsp3, N-(2,5-dihydroxybenzylidene)-thiosemicarbazone, GLYCEROL, ... (7 entities in total)
• Functional Keywords: cystein-protease, inhibitor, sars-cov-2, thiosemicarbazone, deubiquitination, hydrolase
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 1
• Total formula weight: 36659.76

Authors

Ewert, W.,Gunther, S.,Reinke, P.,Falke, S.,Lieske, J.,Miglioli, F.,Carcelli, M.,Srinivasan, V.,Betzel, C.,Han, H.,Lorenzen, K.,Guenther, C.,Niebling, S.,Garcia-Alai, M.,Hinrichs, W.,Rogolino, D.,Meents, A. (deposition date: 2021-11-24, release date: 2022-03-16, Last modification date: 2024-01-31)

• Primary citation: Ewert, W.,Gunther, S.,Miglioli, F.,Falke, S.,Reinke, P.Y.A.,Niebling, S.,Gunther, C.,Han, H.,Srinivasan, V.,Brognaro, H.,Lieske, J.,Lorenzen, K.,Garcia-Alai, M.M.,Betzel, C.,Carcelli, M.,Hinrichs, W.,Rogolino, D.,Meents, A.; Hydrazones and Thiosemicarbazones Targeting Protein-Protein-Interactions of SARS-CoV-2 Papain-like Protease.; Front Chem, 10:832431-832431, 2022; PubMed: 35480391; DOI: 10.3389/fchem.2022.832431

Experimental method

X-RAY DIFFRACTION (1.92 Å)