7QCJ
Structure of SARS-CoV-2 Papain-like Protease bound to N-(2,4-dihydroxybenzylidene)-thiosemicarbazone
Summary for 7QCJ
Entry DOI | 10.2210/pdb7qcj/pdb |
Descriptor | Papain-like protease nsp3, GLYCEROL, N-(2,4-dihydroxybenzylidene)-thiosemicarbazone, ... (7 entities in total) |
Functional Keywords | cystein-protease, inhibitor, sars-cov-2, thiosemicarbazone, deubiquitination, hydrolase |
Biological source | Severe acute respiratory syndrome coronavirus 2 |
Total number of polymer chains | 1 |
Total formula weight | 36886.80 |
Authors | Ewert, W.,Gunther, S.,Reinke, P.,Falke, S.,Lieske, J.,Miglioli, F.,Carcelli, M.,Srinivasan, V.,Betzel, C.,Han, H.,Lorenzen, K.,Guenther, C.,Niebling, S.,Garcia-Alai, M.,Hinrichs, W.,Rogolino, D.,Meents, A. (deposition date: 2021-11-24, release date: 2022-03-16, Last modification date: 2024-01-31) |
Primary citation | Ewert, W.,Gunther, S.,Miglioli, F.,Falke, S.,Reinke, P.Y.A.,Niebling, S.,Gunther, C.,Han, H.,Srinivasan, V.,Brognaro, H.,Lieske, J.,Lorenzen, K.,Garcia-Alai, M.M.,Betzel, C.,Carcelli, M.,Hinrichs, W.,Rogolino, D.,Meents, A. Hydrazones and Thiosemicarbazones Targeting Protein-Protein-Interactions of SARS-CoV-2 Papain-like Protease. Front Chem, 10:832431-832431, 2022 Cited by PubMed: 35480391DOI: 10.3389/fchem.2022.832431 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
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