7QAA

Crystal structure of RARalpha/RXRalpha ligand binding domain heterodimer in complex with BMS614 and oleic acid

Summary for 7QAA

Entry DOI	10.2210/pdb7qaa/pdb
Descriptor	Retinoic acid receptor RXR-alpha, Isoform Alpha-1-deltaBC of Retinoic acid receptor alpha, OLEIC ACID, ... (5 entities in total)
Functional Keywords	nuclear receptor, gene regulation
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	2
Total formula weight	53377.15
Authors	le Maire, A.,Vivat, V.,Guee, L.,Blanc, P.,Malosse, C.,Chamot-Rooke, J.,Germain, P.,Bourguet, w. (deposition date: 2021-11-16, release date: 2022-10-05, Last modification date: 2024-01-31)
Primary citation	le Maire, A.,Rey, M.,Vivat, V.,Guee, L.,Blanc, P.,Malosse, C.,Chamot-Rooke, J.,Germain, P.,Bourguet, W. Design and in vitro characterization of RXR variants as tools to investigate the biological role of endogenous rexinoids. J.Mol.Endocrinol., 69:377-390, 2022 Cited by PubMed: 35900852 DOI: 10.1530/JME-22-0021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.76 Å)

Structure validation