7Q8T

Crystal structure of NAMPT bound to ligand TSY535(compound 9a)

7Q8T の概要

• エントリーDOI: 10.2210/pdb7q8t/pdb
• 分子名称: Nicotinamide phosphoribosyltransferase, [(2~{R},3~{S},4~{R},5~{S})-3,4-bis(oxidanyl)-5-[4-[[[4-(phenylsulfonyl)phenyl]carbamoylamino]methyl]phenyl]oxolan-2-yl]methyl dihydrogen phosphate, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: inhibitor, activator, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 113653.91

構造登録者

Kraemer, A.,Tang, S.,Butterworth, S.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2021-11-11, 公開日: 2021-11-24, 最終更新日: 2024-01-31)

• 主引用文献: Tang, S.,Garzon Sanz, M.,Smith, O.,Kramer, A.,Egbase, D.,Caton, P.W.,Knapp, S.,Butterworth, S.; Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators.; Acta Pharm Sin B, 13:709-721, 2023; PubMed: 36873168; DOI: 10.1016/j.apsb.2022.07.016

実験手法

X-RAY DIFFRACTION (2.15 Å)